Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemolysis after mitral valve replacement with mechanical valve prostheses.

M Ninomiya1, K Yagyu, Y Kaneko

  • 1Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai Zasshi
|May 18, 2001
PubMed
Summary

Mechanical mitral valve prostheses differ in their potential to cause hemolysis. Medtronic-Hall valves showed less late hemolysis compared to St. Jude Medical or CarboMedics valves in patients after mitral valve replacement.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of apheresis techniques and equipment designed for patients weighing less than 10 kg.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2018
Same author

Molecular genetic analysis of 30 families with Joubert syndrome.

Clinical genetics·2016
Same author

Formation of Reducing Substances in the Maillard Reaction between D-Glucose and γ-Aminobutyric Acid.

Bioscience, biotechnology, and biochemistry·2016
Same author

Molecular Biomarker Study in a Randomised Phase III Trial of Irinotecan Plus S-1 versus S-1 for Advanced Gastric Cancer (GC0301/TOP-002).

Clinical oncology (Royal College of Radiologists (Great Britain))·2016
Same author

The expression of miR-125b-5p is increased in the serum of patients with chronic hepatitis B infection and inhibits the detection of hepatitis B virus surface antigen.

Journal of viral hepatitis·2016
Same author

Hiatal Hernia.

Hernia : the journal of hernias and abdominal wall surgery·2015

Area of Science:

  • Biomaterials Science
  • Cardiovascular Surgery
  • Medical Device Engineering

Background:

  • Hemolysis, the destruction of red blood cells, is a potential complication following mechanical heart valve replacement.
  • Understanding factors influencing prosthesis-induced hemolysis is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the impact of mechanical mitral valve prosthesis type, size, and orientation on hemolysis.
  • To compare hemolysis levels across different mechanical mitral valve models.

Main Methods:

  • Lactate dehydrogenase (LDH) levels, a marker for hemolysis, were measured in 84 patients pre-surgery, at 1 month, and in the late postoperative period.
  • Analysis included Medtronic-Hall, St. Jude Medical, and CarboMedics valve types.

Related Experiment Videos

Main Results:

  • Medtronic-Hall valves were associated with less hemolysis in the late postoperative period compared to St. Jude Medical and CarboMedics valves.
  • Hemolysis patterns varied over time: Medtronic-Hall showed higher early hemolysis, while St. Jude Medical and CarboMedics exhibited increased late hemolysis.
  • Increased cardiac output in the late period may exacerbate regurgitation and hemolysis with bileaflet valves.

Conclusions:

  • Medtronic-Hall valves demonstrated a more favorable hemolysis profile in the late postoperative phase compared to St. Jude Medical and CarboMedics valves.
  • Prosthesis type significantly influences hemolysis, with implications for long-term valve performance and patient safety.