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Updated: Jul 13, 2026

Generating Chimeric Zebrafish Embryos by Transplantation
Published on: July 17, 2009
Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A. denis.mcgarry@utsouthwestern.edu
Abstract:
Although malonyl-CoA was first recognized as a central component in the regulation of hepatic ketogenesis, its inhibitory effect on mitochondrial carnitine palmitoyltransferase I (CPT I) has come to be viewed as a key element in fuel sensing in a variety of body tissues. This broadening role of the malonyl-CoA/CPT I partnership in the control of glucose and fatty acid metabolism, as well as current understanding of structure-function relationships surrounding the CPT proteins, are outlined. The intriguing question of whether CPT I has an important function in sperm development is also addressed briefly.
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