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Updated: Jul 22, 2026

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Published on: January 12, 2015
A retro-inverso Prosaptide D5 promotes a myelination process in developing rats
M Hiraiwa1, W M Campana, C Y Wang
1Department of Neurosciences, University of California at San Diego, School of Medicine, Center for Molecular Genetics, La Jolla, CA 92093-0634, USA. mhiraiwa@ucsd.edu
Abstract:
The myelinotrophic action of Prosaptide D5 was investigated in developing rats. Sulfatide concentrations in brain and sciatic nerve were determined to assess the development of myelination. Subcutaneous D5-injection significantly increased sulfatide concentrations in both brain and sciatic nerve by 250 and 150% over controls, respectively. D5 promoted ERK phosphorylation in iSC Schwann cells similar to prosaposin. The results showed that D5 treatment stimulated a myelination process in developing rat.
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