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Related Experiment Videos

Proteomics: a technology-driven and technology-limited discovery science.

K H Lee1

  • 1120 Olin Hall, Chemical Engineering, Cornell University, Ithaca NY 14853-5201, USA. khlee@cheme.cornell.edu

Trends in Biotechnology
|May 18, 2001
PubMed
Summary

Proteomics, the study of the complete protein complement, offers valuable biological insights using tools like 2D electrophoresis and mass spectrometry. Further technological advancements are needed to integrate proteomic data with other biological information for comprehensive system modeling.

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Area of Science:

  • Proteomics and Systems Biology

Background:

  • The proteome represents the complete protein complement of a genome, crucial for understanding biological systems.
  • Current proteomic analysis relies on complementary tools such as 2D protein electrophoresis and mass spectrometry.

Purpose of the Study:

  • To review current technologies for proteome analysis.
  • To highlight the limitations of existing methods and the need for new technologies.

Main Methods:

  • Review of established proteomic analysis tools (2D electrophoresis, mass spectrometry).
  • Discussion of emerging technologies (spotted-array-based methods, microfluidic devices).

Main Results:

  • Existing technologies provide substantial information for discovery-based science.

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  • Key limitations hinder the full integration of proteomic data with other biological datasets.

    • Conclusions:

    • Advanced technologies are required to integrate proteomic data with DNA, mRNA, and metabolite information.
    • Effective biological system models necessitate the comprehensive integration of multi-omics data.