Oligodendroglioma with cystic component in infant
Insights
This case report details a rare pediatric mixed oligodendroglioma with unusual imaging features. Complete surgical removal and adjuvant therapy were performed for this rare brain tumor.
Area of Science:
- Neuro-oncology
- Pediatric Neurology
- Neuroradiology
Background:
- Oligodendrogliomas are rare primary brain tumors, particularly in pediatric populations.
- Mixed oligodendrogliomas, containing components of other glial tumors, present unique diagnostic challenges.
- Intratemporal masses with complex cystic and calcified features are uncommon presentations.
Observation:
- A 6-year-old girl presented with an intratemporal mass exhibiting multilocular cystic formations and extensive intratumoral calcification on CT and MR imaging.
- The neuroradiological findings suggested differential diagnoses including astrocytoma, dysembryoplastic neuroepithelial tumor, or ganglioglioma.
- The mass was surgically excised with near-complete removal.
Findings:
- Histopathological examination confirmed a diagnosis of mixed oligodendroglioma with a minor astrocytoma component.
- The tumor displayed atypical neuroradiological characteristics not typically associated with oligodendroglioma.
Implications:
- This case highlights the importance of considering rare tumor types and presentations in pediatric neuro-oncology.
- Accurate histopathological diagnosis is crucial for appropriate treatment planning in complex pediatric brain tumors.
- Multimodality treatment, including surgery, radiotherapy, and chemotherapy, may be necessary for optimal outcomes in mixed oligodendroglioma.
Abstract:
In this report, we examine the case of a 6-year-old girl with a mixed oligodendroglioma demonstrating uncommon neuroradiological images. CT and MR showed an intratemporal mass with multilocular cystic formation and intratumoral massive calcification, suggestive either of astrocytoma, dysembryoplastic neuroepithelial tumor, or ganglioglioma as a presumptive differential diagnosis. The tumor was almost completely removed. Post-operative histological examination revealed a mixed oligodendroglioma with a small component of astrocytoma. The combination of radiotherapy and chemical treatment was supplemented.
