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Related Experiment Videos

Do white cells matter in white matter damage?

O Dammann1, S Durum, A Leviton

  • 1Children's Hospital and Harvard Medical School, Boston, MA, USA.

Trends in Neurosciences
|May 18, 2001
PubMed
Summary
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Activated leukocytes, particularly monocytes/macrophages, are implicated in damaging the brain's white matter in premature infants. Targeting cell migration may prevent or reduce this neonatal brain damage and subsequent disabilities.

Area of Science:

  • Neuroscience
  • Neonatalogy
  • Immunology

Background:

  • Activated leukocytes, especially monocytes/macrophages, are hypothesized to contribute to cerebral white matter damage in extremely low gestational age newborns.
  • Evidence is largely indirect, drawing from adult brain diseases and animal models of brain injury.

Purpose of the Study:

  • To support the hypothesis linking leukocyte activity to neonatal white matter damage.
  • To explore pharmacological strategies for preventing or reducing this damage.

Main Methods:

  • Review of existing evidence from adult neuropathology and animal models.
  • Hypothetical framework for intervention based on cell migration mechanisms.

Main Results:

Related Experiment Videos

  • Indirect evidence supports the role of activated leukocytes in neonatal white matter injury.
  • The recruitment of circulating cells to the brain is a key proposed mechanism.

    • Conclusions:

    • Minimizing transendothelial cell migration via pharmacological manipulation is a potential strategy.
    • Intervention could prevent or reduce neonatal white matter damage and associated long-term disabilities.