Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variance of ventilation during exercise.

K C Beck1, T A Wilson

  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester 55905, Minnesota, USA. becckk2@mayo.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|May 18, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erroneous prenatal diagnosis of congenital adrenal hyperplasia owing to a duplication of the CYP21A2 gene.

Journal of perinatology : official journal of the California Perinatal Association·2012
Same author

Attenuated relationship between cardiac output and oxygen uptake during high-intensity exercise.

Acta physiologica (Oxford, England)·2011
Same author

Variability in pulmonary function following rapid altitude ascent to the Amundsen-Scott South Pole station.

European journal of applied physiology·2011
Same author

Deformation of a flexible disk bonded to an elastic half space-application to the lung.

Journal of biomechanical engineering·2009
Same author

Regulation of intestinal barrier function by signal transducer and activator of transcription 5b.

Gut·2008
Same author

Glucose metabolism and insulin secretion in a patient with ABCC8 mutation and Fanconi-Bickel syndrome caused by maternal isodisomy of chromosome 3.

Clinical genetics·2007
Same journal

Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

Ventilation distribution in the lungs becomes more uniform during exercise compared to rest. This study measured helium (He) washin in subjects at rest and during exercise, revealing significant differences in ventilation patterns.

Area of Science:

  • Pulmonary physiology
  • Respiratory mechanics
  • Exercise physiology

Background:

  • Lung ventilation distribution is crucial for efficient gas exchange.
  • Understanding how ventilation patterns change with physical activity is important for respiratory health.

Purpose of the Study:

  • To quantify changes in lung ventilation distribution during rest versus exercise.
  • To compare functional ventilation distribution with anatomical data.

Main Methods:

  • Multibreath washin of helium (He) was performed in human subjects.
  • Expired gas concentrations were analyzed.
  • A computational model represented ventilation distribution as a log-normal distribution, fitting standard deviation (sigmaV) to data.

Related Experiment Videos

Main Results:

  • At rest, the standard deviation of ventilation distribution (sigmaV) was 0.89 +/- 0.18.
  • During exercise (70-210 W), sigmaV decreased to 0.60 +/- 0.13, indicating a more uniform ventilation.
  • Functional ventilation distribution was wider than anatomical measurements in animals.

Conclusions:

  • Lung ventilation becomes more uniform during exercise.
  • Ventilation and perfusion are highly correlated at rest, consistent with anatomical data.
  • The structural basis for nonuniform ventilation and perfusion remains unclear.