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Lynestrenol as a contraceptive preparation. Experience with a micro-dosage formulation
Summary
Lynestrenol effectively prevented pregnancy in women. While initial side effects like menstrual disturbances and headaches occurred, they lessened with continued use.
Area of Science:
- Reproductive Medicine
- Pharmacology
Background:
- Oral contraceptives are widely used for pregnancy prevention.
- Understanding the efficacy and side effect profile of specific progestogens is crucial for patient counseling.
Purpose of the Study:
- To evaluate the contraceptive efficacy of daily Lynestrenol 0.5 mg.
- To assess the incidence and nature of side effects associated with Lynestrenol use.
Main Methods:
- A trial involving 143 women of proven fertility.
- Daily administration of Lynestrenol 0.5 mg for 1,082 cycles.
- Monitoring for pregnancies and recording of side effects.
Main Results:
- No unplanned or accidental pregnancies were reported.
- Twenty-three women withdrew, primarily due to menstrual disturbances.
- Initial side effects, including menstrual irregularities, headache, and loss of libido, tended to decrease with continued treatment.
Conclusions:
- Lynestrenol 0.5 mg demonstrates high contraceptive efficacy.
- Menstrual disturbances and other initial side effects are manageable and may improve over time with sustained Lynestrenol use.
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