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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Updated: Jun 26, 2026

DNA Vector-based RNA Interference to Study Gene Function in Cancer
13:10

DNA Vector-based RNA Interference to Study Gene Function in Cancer

Published on: June 4, 2012

Cancer genetics.

B A Ponder1

  • 1CRC Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK. bajp@mole.bio.cam.ac.uk

Nature
|May 18, 2001
PubMed
Summary
This summary is machine-generated.

Cancer research is expanding beyond the cancer cell to include epigenetics and cell interactions. Understanding genetic variation and external factors can improve cancer prevention strategies for at-risk populations.

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Last Updated: Jun 26, 2026

DNA Vector-based RNA Interference to Study Gene Function in Cancer
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Area of Science:

  • Oncology
  • Genetics
  • Epigenetics

Background:

  • Traditional cancer genetics research focused on mutations within cancer cells.
  • Emerging evidence highlights the significance of epigenetic alterations and cellular interactions in cancer development.
  • The role of common genetic variation in population-level cancer susceptibility is gaining recognition.

Purpose of the Study:

  • To broaden the scope of cancer research beyond intracellular mutational events.
  • To integrate the impact of epigenetics, cellular interactions, and common genetic variation into cancer etiology.
  • To leverage Human Genome Project data to understand population susceptibility.

Main Methods:

  • Reviewing current research on epigenetic events and cellular interactions in cancer.
  • Analyzing data on common genetic variation and its link to cancer susceptibility.
  • Utilizing resources from the Human Genome Project.

Main Results:

  • Identified determinants of cancer originating outside the cancer cell.
  • Highlighted the importance of epigenetic modifications and intercellular communication.
  • Recognized the influence of common genetic variations on cancer risk.

Conclusions:

  • Future cancer research must consider factors beyond the cancer cell.
  • New targets for therapeutic intervention can be identified by studying external determinants.
  • Personalized prevention strategies can be developed for high-risk groups based on genetic and environmental factors.