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Extracellular matrix globules in renal oncocytoma
M Guarino1, E Zuccoli, E Garda
1Departments of Anatomical Pathology of D. Cotugno Hospital, Naples, Italy.
Pathology, Research and Practice
|May 19, 2001
Summary
Extracellular hyaline globules are common in renal oncocytomas. Their presence and characteristics, like smooth contours, can help distinguish these tumors from renal cell carcinomas.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Extracellular hyaline globules arise from abnormal matrix accumulation.
- These globules are observed in various pathological conditions, including renal tumors.
Purpose of the Study:
- To investigate the presence and characteristics of extracellular hyaline globules in renal oncocytomas and renal cell carcinomas.
- To determine if these globules can aid in differentiating between these two renal tumor types.
Main Methods:
- Studied 16 renal oncocytomas and 89 renal cell carcinomas.
- Utilized hematoxylin-eosin staining, Periodic Acid-Schiff (PAS) staining, and immunohistochemistry.
- Examined globule morphology, texture, and composition using antibodies for basement membrane components and collagens.
Main Results:
- Hyaline globules were found in 11/16 oncocytomas, often showing homogeneous texture and round, smooth contours.
- PAS staining enhanced globule detection in cases with fewer globules.
- Globules in oncocytomas were strongly positive for type IV collagen, laminin, and heparan sulfate proteoglycan.
- Similar, but fewer and more irregular, globules were observed in 10/89 renal cell carcinomas.
Conclusions:
- The presence of extracellular hyaline globules alone is not sufficient to distinguish renal oncocytoma from renal cell carcinoma.
- A high number of well-demarcated, roundish extracellular globules with smooth contours suggests renal oncocytoma.