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Cardiovascular mortality in hypertensive men according to presence of associated risk factors

F Thomas1, A Rudnichi, A M Bacri

  • 1Centre d'Investigations Préventives et Cliniques, Paris, France.

Hypertension (Dallas, Tex. : 1979)
|May 23, 2001
PubMed

Insights

Hypertension significantly increases cardiovascular disease (CVD) mortality risk. In hypertensive men, associated risk factors amplify this risk, particularly in younger individuals. Older hypertensive men face higher CVD risk primarily due to elevated blood pressure levels.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Hypertension is a major risk factor for cardiovascular disease (CVD).
  • Associated risk factors (ARFs) can further elevate CVD mortality risk in hypertensive individuals.
  • Understanding the interplay between hypertension, ARFs, and age is crucial for risk stratification.

Purpose of the Study:

  • To evaluate the risk of cardiovascular disease (CVD) mortality in hypertensive men based on the presence of associated risk factors (ARFs).
  • To analyze the impact of isolated hypertension and the additive effect of ARFs on CVD mortality across different age groups.

Main Methods:

  • A cohort study involving 29,640 normotensive men and 60,343 hypertensive men.
  • Mortality data analyzed over a mean period of 14 years.
  • ARFs considered: hypercholesterolemia, diabetes, smoking, obesity (BMI >28 kg/m²), and tachycardia (heart rate >80 bpm).

Main Results:

  • Isolated hypertension increased CVD risk linearly with age, from 15% at 30 years to 134% at 80 years.
  • Each additional ARF increased CVD risk by 56% in younger hypertensive men versus 4% in older men.
  • Hypercholesterolemia and smoking had a greater impact on CVD mortality in hypertensive men under 55.

Conclusions:

  • In younger hypertensive men, targeting associated risk factors is essential for CVD risk management.
  • In older hypertensive men, high blood pressure levels are the primary determinant of CVD risk.
  • Age-specific risk assessment and therapeutic strategies are vital for hypertensive populations.

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