Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid hormone metabolism and the developing human lung.

R Hume1, K Richard, E Kaptein

  • 1Department of Obstetrics and Gynaecology, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK. r.hume@dundee.ac.uk

Biology of the Neonate
|May 19, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Diffusion Diaries: Diffusible Iodine-Based Contrast-Enhanced Computed Tomography for Vertebrate Natural History Specimens.

Integrative organismal biology (Oxford, England)·2025
Same author

High-Density Geometric Morphometric Analysis of Intraspecific Cranial Integration in the Barred Grass Snake (<i>Natrix helvetica</i>) and Green Anole (<i>Anolis carolinensis</i>).

Integrative organismal biology (Oxford, England)·2023
Same author

Predicting the Impact of Describing New Species on Phylogenetic Patterns.

Integrative organismal biology (Oxford, England)·2021
Same author

Hypocobalaminaemia as a cause of bone marrow failure and pancytopenia in a cat.

Australian veterinary journal·2017
Same author

Review: Nutrient sulfate supply from mother to fetus: Placental adaptive responses during human and animal gestation.

Placenta·2017
Same author

[Patients' intervention in a therapeutic education program dedicated to systemic lupus: definitions, setting and benefits].

La Revue de medecine interne·2015

Understanding thyroid hormone metabolism in fetuses is key for developing therapies to improve lung development. This research explores how iodothyronines are regulated in the human fetus and infant.

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Perinatology

Background:

  • Thyroid hormones regulate fetal lung development.
  • Antepartum exposure to thyroid hormones and glucocorticoids accelerates lung maturation in animal models.
  • Knowledge of human fetal and infant iodothyronine metabolism is crucial for therapeutic interventions.

Purpose of the Study:

  • To elucidate the regulation of spatial and temporal iodothyronine metabolism in the human fetus and infant.
  • To inform the development of therapies for modifying human lung maturation.

Main Methods:

  • Investigated enzymatic deiodination and reversible sulfation of iodothyronines.
  • Considered fetomaternal and fetoamniotic hormone transfers.
  • Examined fetal thyroid gland production and plasma membrane transporter activities.

Related Experiment Videos

Main Results:

  • Thyroid hormone bioavailability is influenced by enzymatic deiodination and sulfation.
  • Hormone transfers between mother, fetus, and amniotic fluid play a role.
  • Fetal thyroid hormone production and tissue uptake mechanisms are significant factors.

Conclusions:

  • Thyroid hormone metabolism in the human fetus and infant is complex, involving multiple regulatory pathways.
  • Understanding these pathways is essential for future therapeutic strategies targeting fetal lung maturation.