Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selenium and total parenteral nutrition.

A M van Rij, J M McKenzie, M F Robinson

    JPEN. Journal of Parenteral and Enteral Nutrition
    |July 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Predicting medical students who will have difficulty during their clinical training.

    BMC medical education·2017
    Same author

    Comparison of three targeted approaches to screening for abdominal aortic aneurysm based on cardiovascular risk.

    The British journal of surgery·2016
    Same author

    Aortic aneurysm screening.

    The British journal of surgery·2015
    Same author

    Endothelial cell icam-1 staining in human carotid arteries.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Systematic review and meta-analysis: Prevalence and possible causes of vitamin D deficiency and insufficiency in pediatric cancer patients.

    Clinical nutrition (Edinburgh, Scotland)·2015
    Same author

    Ultra-thin strut cobalt chromium bare metal stent usage in a complex real-world setting. (SOLSTICE registry).

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2015
    Same journal

    Associations between ICU survival and self-perceived appetite, smell, and taste relative to general ward patients: A prospective study.

    JPEN. Journal of parenteral and enteral nutrition·2026
    Same journal

    Association between GLIM-defined malnutrition and in-hospital costs in adults with sepsis: A sub analysis of a prospective cohort study.

    JPEN. Journal of parenteral and enteral nutrition·2026
    Same journal

    Postoperative body mass index and the risk of unfavorable outcomes in adults following esophagectomy for esophageal cancer: A retrospective cohort study.

    JPEN. Journal of parenteral and enteral nutrition·2026
    Same journal

    Characterization of patients with medically unexplained intolerance to enteral feeding treated with home parenteral nutrition: A descriptive cohort study.

    JPEN. Journal of parenteral and enteral nutrition·2026
    Same journal

    Association between blood phosphorus level and clinical outcomes in critically ill patients: A systematic review and meta-analysis.

    JPEN. Journal of parenteral and enteral nutrition·2026
    Same journal

    Decreased bone mineral density in adults with type 2 intestinal failure: A descriptive cross-sectional study.

    JPEN. Journal of parenteral and enteral nutrition·2026
    See all related articles

    Patients receiving total parenteral nutrition (TPN) may develop selenium (Se) deficiency. Low blood Se levels were observed, with urinary loss continuing despite low TPN Se content, suggesting supplementation may be needed.

    Area of Science:

    • Biochemistry
    • Clinical Nutrition
    • Trace Element Metabolism

    Background:

    • Selenium (Se) is an essential trace element with increasing recognition in human health.
    • Limited understanding exists regarding Se metabolism during total parenteral nutrition (TPN).
    • High-risk patient populations may be susceptible to developing Se deficiency during TPN.

    Purpose of the Study:

    • To investigate selenium (Se) metabolism in surgical patients receiving TPN.
    • To assess the risk of Se deficiency in patients undergoing TPN.
    • To determine Se levels and loss pathways in TPN-dependent patients.

    Main Methods:

    • Studied 23 surgical patients receiving TPN for at least one week.
    • Assessed whole blood Se levels in TPN patients compared to a low-Se population.

    Related Experiment Videos

  • Monitored Se loss predominantly through urine and gastrointestinal excretion.

    • Main Results:

    • TPN patients exhibited significantly lower whole blood Se levels than the general population.
    • Observed Se levels approached those seen in animals with Se-responsive syndromes.
    • Se continued to be lost via urine despite very low Se content in TPN fluids.
    • Higher gastrointestinal excretion correlated with greater Se loss.

    Conclusions:

    • Patients receiving TPN are at risk for developing selenium deficiency.
    • Urinary Se excretion persists even with minimal Se intake via TPN.
    • Se supplementation may be necessary for certain TPN patients to prevent deficiency.