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Related Experiment Videos

Homologous collagen substances for vocal fold augmentation.

M S Courey1

  • 1Vanderbilt Bill Wilkerson Center for Otolaryngology & Communication Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37212, U.S.A.

The Laryngoscope
|May 19, 2001
PubMed
Summary

This study shows that homologous collagen injections into the thyroarytenoid (TA) muscle can improve vocal fold closure for phonation. These collagen implants are well-tolerated and warrant further clinical trials for dysphonia treatment.

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Area of Science:

  • Laryngology
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Dysphonia due to glottic insufficiency is a challenging clinical issue.
  • Homologous collagen compounds present a potential therapeutic option for voice disorders.
  • Understanding optimal placement and effects of collagen grafts is crucial for effective treatment.

Purpose of the Study:

  • To evaluate collagen graft placement sites and volumes in human vocal folds.
  • To assess the impact of superficial vocal fold implants on laryngeal vibratory patterns and adduction forces.
  • To determine the host response to different forms of cadaveric collagen.

Main Methods:

  • Cadaveric larynges were injected with collagen compounds to assess placement and volume.
  • Laryngeal vibratory patterns and adduction forces were manipulated and measured before and after collagen injection.

Related Experiment Videos

  • A nude mouse model was utilized to evaluate host response to collagen implants.

    • Main Results:

    • Collagen compounds were reliably injected into the superficial lamina propria and thyroarytenoid (TA) muscle.
    • Injection into the TA muscle significantly reduced the force needed for vocal fold adduction without impairing vibration.
    • Both AlloDerm® and Dermalogen® showed good tolerability in mice with minimal inflammation and host integration.

    Conclusions:

    • Homologous collagen can be safely injected into the human larynx, particularly the TA muscle.
    • TA muscle injections effectively reduce the force required for phonation with minimal impact on vocal fold vibration.
    • These collagen materials demonstrate good tolerability and persistence, supporting further clinical investigation for dysphonia.