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Updated: Aug 19, 2026

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis
Published on: November 18, 2019
Mitochondrial polypeptides of the oxidative phosphorylation pathway as potential new targets for anti-cancer therapy
1Department of Viral and Cellular Molecular Genetics, Institute of Molecular Genetics, Moscow, Russia. tarantul@img.ras.ru
Abstract:
We have analyzed our own results on upregulated gene expression in human and monkey lymphomas as well as the data published on expression levels of genes in various cancer cells. The analysis suggests an important role of particular subunits of oxidative phosphorylation (OXPHOS) proteins in malignant transformation of the cell. It opens a possibility of designing new anti-cancer drugs aimed at specific inhibition of the expression of definite mitochondrial OXPHOS proteins' subunits including those of NADH-dehydrogenase 4, cytochrome c oxidase 1, and cytochrome b.
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