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Genetics of allergic disease
M Feijen1, J Gerritsen, D S Postma
1Department of Pulmonary Rehabilitation, Beatrixoord Rehabilitation Centre, Haren, The Netherlands.
British Medical Bulletin
|May 22, 2001
Summary
Genetic factors influence atopy, a condition manifesting as asthma, rhinitis, and eczema. Research identifies multiple genes regulating immunoglobulin E (IgE) levels and clinical symptoms, paving the way for new therapies.
Area of Science:
- Immunology
- Genetics
- Allergy Research
Background:
- Atopy encompasses conditions like asthma, rhinitis, and eczema.
- Diagnostic markers include elevated total and specific immunoglobulin E (IgE), positive skin tests, and eosinophilia.
- Genetic predisposition plays a significant role in atopy development.
Purpose of the Study:
- To explore the genetic underpinnings of atopy.
- To identify genes associated with atopy and its clinical manifestations.
- To understand the genetic regulation of immunoglobulin E (IgE) levels.
Main Methods:
- Review of genetic studies on atopy.
- Analysis of linkage studies identifying chromosomal regions with atopy susceptibility genes.
- Genome-wide screening to detect novel atopy-related genes and candidate genes.
Main Results:
- Multiple genes are implicated in atopy pathogenesis.
- Distinct genes regulate total and specific IgE levels.
- Replicated linkage studies confirm chromosomal regions containing atopy genes.
- Genome-wide screens identified new chromosomal locations harboring atopy genes.
Conclusions:
- Atopy is a complex genetic trait influenced by multiple genes.
- Different genes may control IgE levels and the development of specific atopic phenotypes.
- Further understanding of the genetic basis of atopy is crucial for developing novel therapeutic interventions and early diagnostic strategies.