Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing
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Updated: Oct 7, 2026

RNAi Interference by dsRNA Injection into Drosophila Embryos
Published on: April 11, 2011
H Y Chan1, S Brogna, C J O'Kane
1Department of Genetics, University of Cambridge, Cambridge CB2 3EH, England, United Kingdom.
Abstract:
The Drosophila dribble (dbe) gene encodes a KH domain protein, homologous to yeast KRR1p. Expression of dbe transcripts is ubiquitous during embryogenesis. Overexpressed Dribble protein is localized in the nucleus and in some cell types in a subregion of the nucleolus. Homozygous dbe mutants die at first instar larval stage. Clonal analyses suggest that dbe(+) is required for survival of dividing cells. In dbe mutants, a novel rRNA-processing defect is found and accumulation of an abnormal rRNA precursor is detected.
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