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[Antidiabetic effect of folium mori in GK rats]
Abstract:
The antidiabetic effect of hot water extracts from Folium Mori was investigated in GK rat, one of the animal models of non-insulin dependent diabetic mellitus types. Folium Mori extracts (150 mg/kg) significantly reduced the blood glucose of GK rat from 203.8 +/- 29.8 to 138.5 +/- 21.2 mg/dl at 14 days after oral administration. However, in normal rats, blood glucose and insulin levels were not changed by treatment with Folium Mori. The Folium Mori also decreased blood glucose and improved glucose tolerance at 14 days after repeated administration in GK rats. The Folium Mori treatment significantly increased glucose metabolism in the glucose clamp test for GK rats. These results suggest that Folium Mori has quite unique properties such as raising insulin sensitivity and improving insulin resistance.
Insights
Hot water extracts from Folium Mori (mulberry leaves) effectively lowered blood glucose in diabetic rats. This natural remedy improved glucose metabolism and insulin sensitivity without affecting normal rats.
Area of Science:
- Pharmacology
- Metabolic Disorders
- Natural Product Research
Context:
- Non-insulin dependent diabetes mellitus (NIDDM) is a growing global health concern.
- Animal models like the GK rat are crucial for studying NIDDM pathophysiology and testing potential treatments.
- Traditional herbal medicines are increasingly explored for their therapeutic potential in managing diabetes.
Purpose:
- To investigate the antidiabetic effects of hot water extracts from Folium Mori (mulberry leaves).
- To evaluate the impact of Folium Mori on glucose levels, glucose tolerance, and glucose metabolism in a diabetic rat model.
- To determine if Folium Mori affects insulin sensitivity and resistance.
Summary:
- Folium Mori extracts (150 mg/kg) significantly reduced blood glucose in GK rats from 203.8 +/- 29.8 to 138.5 +/- 21.2 mg/dl within 14 days.
- Repeated administration of Folium Mori improved glucose tolerance and increased glucose metabolism in GK rats, as evidenced by glucose clamp tests.
- No significant changes in blood glucose or insulin levels were observed in normal rats, indicating a specific effect on diabetic models.
Impact:
- Folium Mori demonstrates a significant antidiabetic effect in an animal model of NIDDM.
- The findings suggest Folium Mori enhances insulin sensitivity and improves insulin resistance.
- This research supports the potential of Folium Mori as a natural therapeutic agent for managing type 2 diabetes.