Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reflux esophagitis and airway hyperresponsiveness.

Y Song1, G Li

  • 1First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001.

Chinese Medical Sciences Journal = Chung-Kuo I Hsueh K'O Hsueh Tsa Chih
|May 22, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·1999
Same author

Effect of N-acetylcysteine on UVB-induced apoptosis and DNA repair in human and mouse keratinocytes.

Photochemistry and photobiology·1999
Same author

[Effect of pathogen-stimulated human CD4+ T cells on gamma delta T cells].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·1999
Same author

[Assessment of nutrition in dialysis patients and chronic uremic patients].

Zhonghua nei ke za zhi·1999
Same author

[Clinical evaluation and immunomodulatory study of cefodizime].

Zhonghua nei ke za zhi·1999
Same author

[Effects of high frequency jet ventilation on respiratory airflow and gas exchange in dogs with inhalation injury].

Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns·1999

Reflux esophagitis (RE) impairs lung function and increases airway hyperresponsiveness (AHR). Thromboxane B2 (TXB2) may contribute to AHR in RE patients, suggesting a link between gastrointestinal and respiratory health.

Area of Science:

  • Gastroenterology
  • Pulmonology
  • Pathophysiology

Background:

  • Gastroesophageal reflux disease is common.
  • Reflux esophagitis (RE) may affect respiratory function.
  • Airway hyperresponsiveness (AHR) is a key feature of asthma.

Purpose of the Study:

  • To investigate the impact of RE on lung function.
  • To assess airway reactivity in RE patients.
  • To explore the mechanism of AHR in RE.

Main Methods:

  • Lung function tests and airway provocation were conducted on 31 RE patients and 35 controls.
  • Thromboxane B2 (TXB2) and PGF1a levels were measured.
  • Airway sensitivity was assessed using Dmin.

Main Results:

Related Experiment Videos

  • RE patients exhibited reduced lung function and higher AHR rates compared to controls (P < 0.05).
  • 25% of RE patients showed high airway sensitivity (Dmin < 3 u).
  • Elevated TXB2 levels in RE patients with AHR correlated significantly with airway sensitivity (r = -0.653, P < 0.05).

Conclusions:

  • RE can negatively impact lung function.
  • AHR occurs in 61% of RE patients, with high sensitivity potentially indicating asthma.
  • TXB2 may play a role in the development of AHR in RE.