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Updated: Oct 7, 2026

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
Published on: December 30, 2025
[Effects of human papillomavirus infection on pregnant women and chorionic trophoblasts]
1Affiliated Obstetrics and Gynecology Hospital, Zhejiang University, Hangzhou 310006.
Objective:
To evaluate the effects of human papilloma virus (HPV) infection on pregnant women and chorionic trophoblasts.
Methods:
The morphological characters were observed from 62 pregnant women with codyloma acuminatum during the first and second trimester. In situ hybridization (ISH) was performed to detect HPV 6/11 in chorionic villi of all these cases. In 10 cases, ISH was also performed in condyloma acuminatum of vulva, vaginal and cervix. In 10 cases HPV 6/11 was detected by polymerase chain reaction (PCR) in chorionic villi as well.
Results:
The lesions condyloma acuminatum developed rapidly during pregnancy. Multiple lesions were found usually, and the gross appearances and histological features were more typical. Using ISH and PCR to detect HPV 6/11-DNA in chorionic villi all showed negative. 8 of 10 cases were positive in condyloma acuminatum sites by ISH.
Conclusions:
HPV infection does not make vertical transmission during first and second trimester. It does not increase the potential risk for the fetus.
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