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[A randomized, double-blind, multicentre study on comparing levonorgestrel and mifepristone for emergency
Zhonghua Fu Chan Ke Za Zhi
|May 22, 2001
Summary
Low-dose mifepristone demonstrated higher contraceptive efficacy than levonorgestrel for emergency contraception, with both methods proving safe and well-tolerated. Both treatments had similar effects on the timing and duration of the next menstrual period.
Area of Science:
- Reproductive Health
- Pharmacology
- Clinical Trials
Background:
- Emergency contraception (EC) is crucial for preventing unintended pregnancies.
- Levonorgestrel (LNG) and mifepristone are common EC methods.
- Comparative data on low-dose mifepristone and LNG efficacy is important.
Purpose of the Study:
- To compare the efficacy of levonorgestrel (LNG) versus low-dose mifepristone for emergency contraception.
- To assess and compare the side effects of both EC methods.
- To evaluate the impact of LNG and mifepristone on the subsequent menstrual cycle.
Main Methods:
- A randomized, double-blind, multicenter comparative trial was conducted.
- Participants received either LNG (0.75 mg twice) or a single dose of mifepristone (10 mg).
- Efficacy, side effects, and menstrual patterns were assessed through follow-up visits.
Main Results:
- Mifepristone showed a higher contraceptive efficacy rate (79.7%) compared to LNG (59.2%), with a statistically significant difference (P < 0.05).
- Pregnancy rates were lower in the mifepristone group (1.4%) versus the LNG group (3.1%).
- Both methods exhibited mild side effects (<10.0%) with no significant differences between groups, and similar effects on menstrual cycle timing and duration.
Conclusions:
- Both levonorgestrel and low-dose mifepristone are effective and safe options for emergency contraception.
- Low-dose mifepristone appears to be more effective in preventing pregnancy compared to levonorgestrel.
- Neither EC method significantly altered menstrual cycle regularity or duration.