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[Relationship between histopathologic observation of cervical condyloma and human papillomavirus infection]
Objective:
To study the relationship between histopathologic changes of cervical condyloma and different subtypes human papillomavirus (HPV) infection.
Methods:
158 women with abnormal Pap smears diagnosed by computer assisted cytologic technique (CCT) including 71 cases with atypical squamous cells of undetermined significance (ASCUS), 65 cases with low-grade squamous intraepithelial lesions (LSIL), 17 cases with high-grade squamous intraepithelial lesions (HSIL) and 5 cases with squamous cancers, underwent directed biopsies under colposcopy and were simultaneously detected for HPV6/11, HPV16/18 DNA by polymerase chain reaction (PCR). Koilocytotisis in 73 cases with pathologically proven cervical condyloma were grouped into type I and II according to its atypical degree of nuclei.
Results:
HPV16/18 infection rate among condylomas cases was 86.0%, which was significantly higher than that of type I (16.7%) (P < 0.01). In LSIL with type II koilocytotisis, HPV16/18 infection rate and abnormal mitotic figures (AMFs) occurrence were 85.7%, significantly higher than those in type I koilocytotisis or cervical intraepithelial neoplasia I.
Conclusions:
Type II koilocytotisis was correlated with HPV16/18 infection. LSIL with type II koilocytotisises, distinct atypical nuclei, also associated with high HPV16/18 rate and AMFs, therefore treatment and follow-up should be more aggressive.