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Updated: Aug 1, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
[The relationship between fetal fibronectin, bacteria vaginosis and chorioammionitis]
Objective:
To study the relationship of fetal fibronectin (FFN), Bacteria vaginosis (BV) and chorioamnionitis. To evaluate the diagnostic value of FFN for chorioamnionitis.
Methods:
FFN was measured by enzyme-labelled immunosordent assay (ELISA) in samples of carvical secretion from 60 pregnant women with BV (study group) and 45 normal pregnant women at same gestational weeks (control group). Positive test was defined as a level of (FFN) > or = 50 ng/ml.
Results:
Positive rate of FFN in pregnant women with BV was significantly higher than that in the normal control group. Incidence of chorioamnionitis and preterm labor in FFN positive cases was significantly higher than that of FFN negative cases.
Conclusions:
Fetal fibronectin is an important marker for diagnosis and prediction of chorioamnionitis perterm labor and Premature rupture of membranes.
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