Related Experiment Videos
Genetic polymorphism of CYP2D6 in Karnataka and Andhra Pradesh population in India
B K Abraham1, C Adithan, P U Kiran
1Clinical Pharmacology Unit, Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry-605 006, India.
Aim:
To study the prevalence of cytochrome P-450 2D6 (CYP2D6) polymorphism in Karnataka (KA) and Andhra Pradesh (AP) population.
Methods:
Two hundred and eleven healthy human volunteers participated in the study (100 from KA and 111 from AP). At bed time, after voiding their bladder, the volunteers ingested 30 mg of dextromethorphan hydrobromide (DM). Urine samples were collected for 8 h. DM and its metabolite dextrorphan (DT) were estimated in the urine using HPLC. The metabolic ratio (DM/DT) was used for phenotyping.
Results:
The prevalence of poor metabolisers (PM) in KA is 4% and AP is 1.8%.
Conclusion:
The frequency of PM phenotype in South Indian population is in between the Western and Oriental population.
Related Concept Videos
Principles of Pharmacogenetics: Types of Genetic Variants
Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes
Pharmacogenetics of Drug Metabolism: Overview
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters