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[High resolution and spirometric synchronization computerized tomography in chronic obstructive bronchopneumopathy].

C Moroni1, M Mascalchi, M Bartolucci

  • 1Sezione di Radiodiagnostica, Dipartimento di Fisiopatologia Clinica, Università degli Studi, Firenze.

La Radiologia Medica
|May 22, 2001
PubMed
Summary
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Spirometrically gated high-resolution computed tomography (HRCT) shows good correlation with pulmonary function tests in patients with chronic obstructive pulmonary disease. This technique is a promising tool for assessing obstructive lung disease severity and progression.

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Medical Imaging

Background:

  • Chronic obstructive pulmonary disease (COPD) requires accurate assessment of disease severity.
  • Pulmonary function tests (PFTs) are standard for evaluating COPD.
  • High-resolution computed tomography (HRCT) can visualize lung parenchyma, but its correlation with PFTs needs further investigation.

Purpose of the Study:

  • To evaluate the feasibility of spirometrically gated HRCT in COPD patients.
  • To correlate HRCT-derived density measures with PFT results.

Main Methods:

  • 20 COPD patients underwent spirometrically gated HRCT at 90% and 10% vital capacity.
  • Lung parenchyma densitometry was performed using region of interest analysis.
  • CT numbers and pixel indices were calculated and correlated with PFTs.

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Main Results:

  • Mean CT number and pixel index at 10% vital capacity correlated with Tiffeneau index (r=0.85, R=0.78).
  • Pixel index at 10% vital capacity correlated with RV/TLC ratio (r=0.65).
  • Mean CT number and pixel index at 90% vital capacity correlated with carbon monoxide diffusion (r=0.64, r=0.79).

Conclusions:

  • Spirometrically gated HRCT densitometry shows good correlation with standard PFTs in COPD.
  • Spirometric gating ensures reproducibility by standardizing lung volume.
  • This technique is a promising tool for longitudinal studies of diffuse lung diseases like emphysema and fibrosis.