Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Ischemic preconditioning: implications for the geriatric heart.

R A Kloner¹, T Shook, C P Cannon

¹Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, Los Angeles, CA 90017, USA.

The American Journal of Geriatric Cardiology

|May 22, 2001

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Randomized Evaluation of the Effects of Anacetrapib through Lipid-modification (REVEAL)-A large-scale, randomized, placebo-controlled trial of the clinical effects of anacetrapib among people with established vascular disease: Trial design, recruitment, and baseline characteristics.

American heart journal·2017

Same author

Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes.

Diabetes, obesity & metabolism·2015

Same author

The effects of proton pump inhibition on patient-reported severity of dyspepsia when receiving dual anti-platelet therapy with clopidogrel and low-dose aspirin: analysis from the Clopidogrel and the Optimization of Gastrointestinal Events Trial.

Alimentary pharmacology & therapeutics·2015

Same author

Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials.

Lancet (London, England)·2015

Same author

Health economic analysis of ticagrelor in patients with acute coronary syndromes intended for non-invasive therapy.

Heart (British Cardiac Society)·2014

Same author

Risk factors for NSAID-associated upper GI clinical events in a long-term prospective study of 34 701 arthritis patients.

Alimentary pharmacology & therapeutics·2010

Ischemic preconditioning can reduce heart attack damage. Older adults (>=60) with a history of angina may benefit from this protective effect, suggesting preconditioning is possible in the senescent heart.

Area of Science:

Cardiology
Cardiovascular Research
Geriatric Medicine

Background:

Ischemic preconditioning is a potent endogenous cardioprotective mechanism.
Clinical evidence suggests the human heart can undergo preconditioning.
Controversy remains regarding preconditioning efficacy in the aging (senescent) heart.

Purpose of the Study:

To investigate the potential for ischemic preconditioning in older adults.
To explore whether a history of angina confers protection in elderly patients experiencing acute myocardial infarction.

Main Methods:

Analysis of data from the Thrombolysis in Myocardial Infarction-4 (TIMI-4) clinical trial.
Comparison of outcomes in older patients (>=60 years) with and without a history of angina prior to myocardial infarction.

Related Experiment Videos

Main Results:

Older patients (>=60 years) with a history of angina showed a potential benefit.
This suggests a possible clinical manifestation of preconditioning in the senescent heart.

Conclusions:

The findings suggest that the aging human heart may be amenable to ischemic preconditioning.
A history of angina prior to myocardial infarction may represent a clinical correlate of preconditioning in the elderly.
Further research is warranted to confirm and elucidate this cardioprotective phenomenon in older populations.