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Remission in psoriatic arthritis
D D Gladman1, E N Hing, C T Schentag
1University of Toronto Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada.
The Journal of Rheumatology
|May 22, 2001
Summary
Remission is achievable in psoriatic arthritis (PsA), with 17.6% of patients achieving it. Early clinical features like male sex and fewer joint issues predict sustained remission in PsA patients.
Area of Science:
- Rheumatology
- Immunology
- Clinical Medicine
Background:
- Psoriatic arthritis (PsA) is a chronic inflammatory condition.
- Understanding remission rates and predictors is crucial for managing PsA.
- Previous studies have varied in defining and assessing remission.
Purpose of the Study:
- To determine the frequency of remission in psoriatic arthritis (PsA).
- To describe the characteristics of remission in PsA.
- To identify features associated with achieving remission in PsA.
Main Methods:
- Prospective follow-up of PsA patients with peripheral arthritis and at least 3 visits.
- Definition of sustained remission: no active joint inflammation across 3 consecutive visits.
- Comparison of patients in sustained remission versus those with persistent inflammation.
Main Results:
- 17.6% of 391 eligible PsA patients achieved sustained remission.
- The average remission duration was 2.6 years, but 52% experienced flares.
- Male sex, fewer inflamed/damaged joints, and better initial functional class predicted remission.
Conclusions:
- Sustained remission is possible in PsA and can be prolonged.
- Specific baseline clinical characteristics identify PsA patients likely to achieve remission.