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Updated: Aug 6, 2026
Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
Published on: December 27, 2010
HIV-1 infection in a population-based twin sample
K Krasinski1, B J Turner, W W Hauck
1New York University Medical Center-Bellevue Hospital Center, New York, USA.
Objective:
To examine factors associated with perinatal HIV-1 transmission among twins.
Methods:
We identified twins delivered by a population-based cohort of HIV-infected mothers on New York State Medicaid. Tested algorithms were applied to Medicaid files to identify HIV infection in mothers and twins. The HIV transmission rate 3 years after delivery was assessed from Kaplan-Meier curves. Proportional hazards models with adjustment for twin clustering were used to determine the relative hazard (RH) of transmission.
Results:
In 35 twin pairs, transmission was 20.5%. The risk of transmission was increased significantly for advanced maternal HIV infection (rh = 10.8, 95% confidence interval 2.11, 54.9). We found no association of birth order with twin HIV status.
Conclusions:
These data suggest that maternal stage of disease plays a greater role in vertical HIV transmission than birth order. To prevent maternal-child HIV transmission, reducing maternal viral load is likely to have a greater impact than modifying delivery factors.
