Clinico-pathological correlations in a case of traumatic pan-hypopituitarism

A case of post-traumatic chronic pan-hypopituitarism in a 22 year old man is reported. Post-mortem examination revealed gliosis of the posterior hypothalamus, sclerosis of the neuro-hypophysis, cellular atrophy of the adenohypophysis, with relative hyperplasia of the basophil cells, atrophy of the endocrine target glands. Clinical and morphological findings are correlated and discussed.