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Updated: Aug 7, 2026

Live Imaging of Dense-core Vesicles in Primary Cultured Hippocampal Neurons
Published on: May 29, 2009
The large dense core vesicle: a normal organelle of the central nervous system myelinated axon
Abstract:
Large dense core vesicles (LDCV) were found frequently enough in normal guinea pig central white matter, basis pontis and spinal cord posterior columns to be regarded as a normal organelle. A review of studies of LDCV and dense core particles (DCP), which have a different cytological localization and appear to be associated with a variety of diseases, suggests that they are the same, and hence remarkedly ubiquitous. LDCV should no longer be regarded as a type of synaptic vesicle, but as an incompetely defined organelle common to many cell types.
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