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Published on: December 5, 2017
[Deletion polymorphism in the angiotensin converting enzyme gene associated with essential hypertension in Hans
Objective:
To investigate whether the polymorphism of the angiotensin-converting enzyme(ACE) gene is associated with essential hypertension in Chinese.
Methods:
A case-control study was carried out using 134 hypertensive (HT) and 165 normotensive (NT) subjects. The insertion/deletion (I/D) polymorphism of ACE gene was detected by polymerase chain reaction (PCR).
Results:
The difference of genotype and derived allele frequencies for deletion of ACE gene between hypertensive and normotensive subjects were statistically significant(i.e. 51.9% vs 15.7 and 0.69 vs 0.31 for hypertensive and normotensive respectively, P < 0.05).
Conclusions:
The possession of D/D homozygote genotype of the ACE gene might be a marker for genetic susceptibility to Hans hypertension in Chinese.
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