Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Liver angiosarcoma in humans: epidemiologic considerations].

C Zocchetti1

  • 1Regione Lombardia, Osservatorio Epidemiologico e Flussi Informativi, Via Pola, 9-20124 Milano. Carlo_Zocchetti@regione.lombardia.it

La Medicina Del Lavoro
|May 23, 2001
PubMed
Summary

Angiosarcoma of the liver is a rare cancer with unknown causes, despite research. Vinyl chloride monomer is a confirmed occupational risk factor, but other substances explain less than 20% of cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Mesothelioma and acceleration].

La Medicina del lavoro·2015
Same author

III Italian Consensus Conference on Malignant Mesothelioma of the Pleura. Epidemiology, Public Health and Occupational Medicine related issues.

La Medicina del lavoro·2015
Same author

[Health expenditures for cases of pleural mesothelioma].

La Medicina del lavoro·2015
Same author

[Regarding the "Report of the Second Italian Consensus Conference of Pleural Mesothelioma"].

La Medicina del lavoro·2014
Same author

[Pier Luigi Viola and vinyl chloride: notes that were never published].

La Medicina del lavoro·2010
Same author

[Acroosteolysis in PVC autoclave cleaners: history of an occupational disease].

La Medicina del lavoro·2010

Area of Science:

  • Epidemiology
  • Oncology
  • Toxicology

Context:

  • Angiosarcoma of the liver is an exceptionally rare malignancy.
  • It presents diagnostic challenges and occurs across all ages and genders.
  • Established risk factors explain a minority of cases.

Purpose:

  • To review the epidemiologic literature on liver angiosarcoma.
  • To identify known and potential risk factors for this rare cancer.
  • To assess the current understanding of its etiology.

Summary:

  • Liver angiosarcoma is rare (0.5-2.5 per 10,000,000), with long latency periods (10-60+ years).
  • Known risk factors like Thorotrast, arsenic, and vinyl chloride monomer (VCM) explain <20% of cases.
  • Occupational VCM exposure (pre-1970, autoclave cleaners) is linked to male cases (35-75 yrs, 22-yr latency); environmental VCM exposure shows no link.

Related Experiment Videos

Impact:

  • Highlights the limited understanding of angiosarcoma of the liver etiology beyond VCM.
  • Underscores the need for further research into the causes of this rare cancer.
  • Informs occupational health and safety regarding VCM exposure risks.