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[Changes in intake pattern in obese patients treated with paroxetine]
D A de Luis1, J de Luis, R Aller
1Instituto de Endocrinología y Nutrición (IEN), Facultad de Medicina y Hospital Río Hortega, Universidad de Valladolid, España.
Nutricion Hospitalaria
|May 23, 2001
Summary
Paroxetine significantly reduced calorie, protein, and carbohydrate intake in obese patients compared to diet alone. This study highlights paroxetine
Area of Science:
- Obesity pharmacotherapy
- Nutritional science
- Clinical nutrition
Background:
- Obesity management involves thermogenesis, fat absorption reduction, or appetite suppression.
- Appetite suppressants may alter dietary intake patterns.
- Paroxetine is an antidepressant with potential effects on appetite.
Purpose of the Study:
- To evaluate changes in eating habits and dietary adherence in obese patients treated with paroxetine.
- To compare the dietary intake of obese patients on a 1,500-calorie diet with and without paroxetine.
Main Methods:
- A study involving 14 obese patients divided into two groups: diet only (n=7) and diet plus paroxetine (n=7).
- All participants followed a 1,500-calorie daily diet for three months.
- A 24-hour nutritional survey assessed habitual intake versus recommended intake.
Main Results:
- Patients receiving paroxetine consumed significantly fewer total calories (1,403 vs. 2,094 kcal/day), protein (63 vs. 100 g/day), and carbohydrates (164 vs. 218 g/day).
- No significant differences were observed in fat intake between groups.
- Paroxetine group showed lower intake of iron, phosphorus, and potassium.
Conclusions:
- Paroxetine modifies dietary intake patterns by reducing consumption of calories, protein, and carbohydrates.
- These findings suggest paroxetine's potential role in managing obesity through appetite suppression and altered eating habits.
- Further research is warranted to explore the long-term effects and mechanisms of paroxetine in obesity treatment.