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HIV in cervical cancer.

S V Wallace1, E M Carlin

  • 1Department of Genitourinary Medicine, Nottingham City Hospital NHS Trust, Hucknall Road, Nottingham NG5 1PB, UK.

International Journal of STD & AIDS
|May 23, 2001
PubMed
Summary

Women with HIV face higher risks of cervical cancer. This review examines if cervical cancer patients should be screened for HIV and assesses the cost-effectiveness of such screening strategies.

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Area of Science:

  • Gynecology
  • Infectious Diseases
  • Oncology

Background:

  • Women represent a growing segment of the human immunodeficiency virus (HIV)-infected population.
  • HIV-infected women exhibit increased incidence and more aggressive progression of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer compared to HIV-negative women.
  • Invasive cervical carcinoma is an AIDS-defining diagnosis in HIV-infected individuals.

Purpose of the Study:

  • To review the association between HIV infection and cervical cancer.
  • To determine if cervical cancer screening for HIV infection is warranted.
  • To assess the cost-effectiveness of HIV screening in women diagnosed with cervical cancer.

Main Methods:

  • Literature review of studies on HIV and cervical cancer.
  • Analysis of epidemiological data on CIN and invasive cervical cancer in HIV-infected women.
  • Cost-effectiveness analysis of proposed screening strategies.

Main Results:

  • HIV-infected women have a significantly higher risk of developing and progressing cervical cancer.
  • The review addresses the clinical and public health implications of these findings.
  • A cost-effectiveness assessment of screening interventions is provided.

Conclusions:

  • The heightened risk of aggressive cervical cancer in women with HIV necessitates careful consideration of screening protocols.
  • The review provides evidence to inform guidelines on HIV screening for women diagnosed with cervical cancer.
  • Implementing cost-effective screening can improve outcomes for this vulnerable population.

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