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Concordance of deficit and non-deficit subtypes in siblings affected with schizophrenia
G Fouldrin1, M Jay, F Bonnet-Brilhault
1Unité INSERM EPI-9906, Université de Rouen, Service Hospitalo-Universitaire de Psychiatrie, CHRU C. Nicolle and CH du Rouvray, 1 Rue de Germont, F-76031, Rouen Cedex, France.
Psychiatry Research
|May 23, 2001
Abstract:
Deficit and non-deficit subtypes were examined for their concordance in 83 sibling pairs of 109 schizophrenic patients belonging to 46 multiply affected families. Using a sib-pair method, we have found that the distribution of deficit and non-deficit syndromes in sibling pairs of schizophrenic patients differed significantly from chance expectation. This familial aggregation suggests that the syndrome may be used to define phenotypes for genetic studies.