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Updated: Jul 30, 2026
08:44
Generation and Purification of Human INO80 Chromatin Remodeling Complexes and Subcomplexes
Published on: October 23, 2014
The BAH domain, polybromo and the RSC chromatin remodelling complex
1Institute of Cancer Research, Haddow Laboratories, Department of Molecular Carcinogenesis, 15 Cotswold Road, SN2 5NG, England, Sutton, UK. goodwin@icr.ac.uk
Gene
|May 23, 2001
Summary
The Bromo-adjacent homology (BAH) domain is crucial for gene transcription and repression. This review explores BAH and bromodomain functions in vertebrate polybromo and yeast Rsc proteins involved in chromatin remodeling.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- The Bromo-adjacent homology (BAH) domain is a conserved protein module.
- It was first identified in vertebrate polybromo proteins, which are part of large nuclear complexes.
- Polybromo proteins contain BAH domains, bromodomains, and an HMG-box, suggesting roles in transcriptional regulation.
Purpose of the Study:
- To review recent data on the functional roles of BAH and bromodomains.
- To explore the relationship between BAH domains in vertebrate polybromo proteins and yeast Rsc proteins.
- To understand the involvement of these domains in gene transcription and protein-protein interactions.
Main Methods:
- Literature review of recent research data.
- Comparative analysis of protein domain functions across species.
- Focus on proteins involved in gene transcription, repression, and chromatin remodeling.
Main Results:
- BAH domains are implicated in both gene transcription and repression.
- These domains are likely involved in mediating protein-protein interactions.
- Yeast Rsc1 and Rsc2 proteins, containing BAH domains and AT-hooks, are components of the RSC complex essential for transcriptional control.
Conclusions:
- BAH and bromodomains play significant roles in the regulation of gene expression.
- Functional similarities exist between vertebrate polybromo proteins and yeast Rsc proteins regarding these domains.
- Further research into these domains can elucidate mechanisms of transcriptional control and chromatin organization.
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