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Related Experiment Videos

Oxidative damage to proteins and decrease of antioxidant capacity in patients with varicocele.

S S Chen1, L S Chang, Y H Wei

  • 1Institute of Clinical Medicine, National Yang-Ming University, Taipei, Republic of Taiwan, China.

Free Radical Biology & Medicine
|May 23, 2001
PubMed
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Oxidative stress is elevated in men with varicocele and subclinical varicocele, indicated by higher plasma protein carbonyls and lower seminal plasma antioxidants. These markers can help assess oxidative stress in varicocele patients.

Area of Science:

  • Reproductive Medicine
  • Biochemistry
  • Oxidative Stress Research

Background:

  • Varicocele is associated with male infertility.
  • Oxidative stress is implicated in the pathophysiology of varicocele.
  • Biomarkers for oxidative stress in varicocele are needed.

Purpose of the Study:

  • To investigate oxidative damage to blood proteins in the spermatic vein.
  • To assess seminal plasma antioxidant capacity in patients with varicocele and subclinical varicocele.
  • To identify potential biomarkers for oxidative stress in varicocele.

Main Methods:

  • Spectrophotometric assays were used to measure plasma protein carbonyls, seminal plasma protein thiols, and ascorbic acid levels.
  • Blood samples were collected from peripheral and spermatic veins.

Related Experiment Videos

  • Participants included patients with varicocele, subclinical varicocele, and healthy controls.

    • Main Results:

    • Plasma protein carbonyls were significantly higher in spermatic veins compared to peripheral veins in varicocele and subclinical varicocele groups.
    • Spermatic vein protein carbonyls were elevated in varicocele and subclinical varicocele patients compared to controls.
    • Seminal plasma protein thiols and ascorbic acid levels were significantly lower in the varicocele group compared to controls.

    Conclusions:

    • Patients with varicocele and subclinical varicocele exhibit increased oxidative stress.
    • Plasma protein carbonyls and seminal plasma antioxidants (protein thiols, ascorbic acid) are potential markers for assessing oxidative stress in varicocele.
    • These findings contribute to understanding the role of oxidative stress in varicocele pathophysiology.