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Sidestream cigarette smoke accelerates atherogenesis in apolipoprotein E-/- mice.

C G Gairola1, M L Drawdy, A E Block

  • 1Graduate Center for Toxicology, College of Pharmacy, 229 THRI Bldg., University of Kentucky, Lexington, KY 40546-0236, USA. cggair01@pop.uky.edu

Atherosclerosis
|May 23, 2001
PubMed
Summary
This summary is machine-generated.

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Exposure to environmental tobacco smoke, or sidestream cigarette smoke (SSCS), significantly accelerates atherosclerosis development in mice. This study demonstrates that SSCS promotes the buildup of arterial plaques, increasing cardiovascular disease risk.

Area of Science:

  • Cardiovascular Science
  • Toxicology
  • Atherosclerosis Research

Background:

  • Epidemiological data link active and passive smoking to elevated cardiovascular disease (CVD) risk.
  • Environmental tobacco smoke (ETS) is a significant public health concern, but its direct impact on atherogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the pro-atherogenic effects of sidestream cigarette smoke (SSCS), a key component of ETS.
  • To determine if SSCS exposure promotes the development of atherosclerotic lesions in a relevant animal model.

Main Methods:

  • Female ApoE-deficient mice on a Western diet were exposed to SSCS or filtered air (control) for 7, 10, or 14 weeks.
  • Exposure effectiveness was confirmed by measuring blood carboxyhemoglobin and pulmonary CYP1A1 levels.

Related Experiment Videos

  • Aortic atherosclerotic lesion development was quantified using morphometric and en face analyses.

    • Main Results:

    • SSCS exposure led to significant increases in aortic atherosclerotic lesion area across all study durations.
    • No consistent alterations in serum cholesterol levels were observed between SSCS-exposed and control groups.
    • Increased aortic lesion area correlated with elevated levels of both esterified and unesterified cholesterol within aortic tissues.

    Conclusions:

    • Sidestream cigarette smoke (SSCS) demonstrably promotes atherosclerotic lesion development.
    • Tobacco smoke exposure accelerates atherogenesis in a mouse model susceptible to human atherosclerosis.
    • These findings highlight the detrimental cardiovascular impact of environmental tobacco smoke exposure.