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Related Experiment Videos

Mathematical models describing polymer dissolution: consequences for drug delivery.

B Narasimhan1

  • 1Department of Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ 08854-8058, USA. balaji@sol.rutgers.edu

Advanced Drug Delivery Reviews
|May 23, 2001
PubMed
Summary

This review explores polymer dissolution modeling for drug release. It covers phenomenological and anomalous transport models, finding experimental results align with current theories.

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Area of Science:

  • Polymer Science and Engineering
  • Materials Science
  • Chemical Engineering

Background:

  • Polymer dissolution is crucial for applications such as drug delivery and recycling.
  • Understanding the physics of dissolution is key to optimizing these applications.
  • Experimental observations of polymer dissolution behavior are well-documented.

Purpose of the Study:

  • To review and classify modeling approaches for polymer dissolution.
  • To elucidate the physics governing drug release from dissolving polymers.
  • To compare model predictions with experimental findings.

Main Methods:

  • Classification of modeling approaches into phenomenological and anomalous transport categories.
  • Discussion of underlying principles and key features of each modeling approach.

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  • Analysis of specific models and their predictive capabilities.

    • Main Results:

    • Two primary modeling frameworks exist: phenomenological/Fickian and anomalous transport/scaling law-based.
    • Detailed insights into various models and their predictions are presented.
    • Qualitative agreement between experimental data and theoretical models is observed.

    Conclusions:

    • Current modeling approaches provide a robust framework for understanding polymer dissolution.
    • The physics of drug release from dissolving polymers is increasingly well-understood.
    • Further research can refine these models for enhanced application design.