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Intracellular assembly of VLDL: two major steps in separate cell compartments
S O Olofsson1, P Stillemark-Billton, L Asp
1Department of Medical Biochemistry and the Wallenberg Laboratory for Cardiovascular Research, University of Göteborg, Göteborg, Sweden. Sven-Olof. Olofsson@mdkem.gu.se
Trends in Cardiovascular Medicine
|May 23, 2001
Abstract:
The assembly of very low-density lipoproteins (VLDL) occurs in two major steps. The first step is the co-and post-translational lipidation of apoB, forming pre-VLDL in the rough endoplasmic reticulum. The microsomal triglyceride transfer protein catalyzes this step. In the second step pre-VLDL is converted to bona fide VLDL in a smooth membrane compartment. This step depends on ADP-ribosylation factor 1 and its activation of phospholipase D.