Related Experiment Video
Updated: Oct 7, 2026

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
New quinolones and the impact on resistance
T J. Dougherty1, D Beaulieu, J F. Barrett
1Department of Microbiology, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, 06492, Wallingford, CT, USA
Abstract:
The changes in quinolone research have been fast and exciting over the past 5-7 years with the discovery and development of several new 8-methoxy quinolones. An additional factor is the design of the so-called 4th-generation quinolones that lack the C-6 fluorine, which might impact the development of quinolone resistance. The science behind the quinolone susceptibility and resistance patterns is fascinating, but has not yet been clearly delineated in discussions of the advantages of quinolone usage in the clinic.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
Mechanism of Antibiotic Resistance in MRSA
Gene Regulation in Microbial Communities: Quorum Sensing
Clinical Significance of Antibiotic Resistance
Development of Antibiotic Resistance
Inhibitors of Bacterial Protein Synthesis

