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Actin is oxidized during myocardial ischemia
S R Powell1, E M Gurzenda, S E Wahezi
1Maternal/Fetal Medicine Research Lab., Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, NY 11501, USA. spowell@winthrop.org
Free Radical Biology & Medicine
|May 23, 2001
Abstract:
Exposure of isolated rat hearts to 30 min global ischemia followed by 60 min reperfusion resulted in a significant 80% increase (p <.05) in actin content of carbonyl groups, which was associated with significant depression (p <.05) of postischemic contractile function. This result supports the hypothesis that one mechanism of postischemic contractile dysfunction may be oxidation of contractile proteins.