Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac involvement in thalassemia intermedia: a multicenter study.

A Aessopos1, D Farmakis, M Karagiorga

  • 1First Department of Internal Medicine, University of Athens School of Medicine, Laiko General Hospital, 17 Aghiou Thoma Street, Athens 115 27, Greece.

Blood
|May 23, 2001
PubMed
Summary

Pulmonary hypertension (PHT) is the main cardiac issue in thalassemia intermedia (TI) patients, leading to congestive heart failure (CHF). High cardiac output (CO) and pulmonary resistance (PVR) contribute to PHT in TI.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

European Society of Cardiology quality indicators for the prevention and management of cancer therapy-related cardiovascular toxicity in cancer treatment.

European heart journal. Quality of care & clinical outcomes·2022
Same author

A cost-utility analysis of increasing percutaneous coronary intervention use in elderly patients with acute coronary syndromes in six European countries.

European journal of preventive cardiology·2021
Same author

Effect of heterozygous beta thalassemia on HbA1c levels in individuals without diabetes mellitus: A cross sectional study.

Clinica chimica acta; international journal of clinical chemistry·2019
Same author

A simple score for early risk stratification in acute heart failure.

International journal of cardiology·2017
Same author

The heart failure pandemic: The clinical and economic burden in Greece.

International journal of cardiology·2016
Same author

Fetal Erythropoiesis after Allogeneic Bone Marrow Transplantation Estimated by the Peripheral Blood Erythrocytes Containing Hemoglobin F (F-cells).

Hematology (Amsterdam, Netherlands)·2016

Area of Science:

  • Cardiology
  • Hematology
  • Internal Medicine

Background:

  • Thalassemia intermedia (TI) is a chronic blood disorder with significant cardiac complications.
  • Cardiac issues in TI patients are often linked to disease severity and transfusion history.
  • Pulmonary hypertension (PHT) is a recognized but not fully understood complication in TI.

Purpose of the Study:

  • To investigate cardiac complications in patients with thalassemia intermedia (TI).
  • To identify the prevalence and contributing factors of pulmonary hypertension (PHT) in TI.
  • To evaluate the role of PHT as a cause of congestive heart failure (CHF) in TI.

Main Methods:

  • Studied 110 TI patients and 76 healthy controls.
  • Utilized medical history, clinical examination, ECG, chest X-ray, and echocardiography.

Related Experiment Videos

  • Included cardiac catheterization in 6 patients with CHF.

    • Main Results:

    • Pulmonary hypertension (PHT) affected 59.1% of TI patients, correlating with age and cardiac output (CO).
    • Valvular abnormalities (48.1% leaflet thickening, 20.9% calcification, 15.4% aortic regurgitation, 47.2% mitral regurgitation) were common.
    • Congestive heart failure (CHF) was present in 5.4% of patients, linked to severe PHT.

    Conclusions:

    • Pulmonary hypertension (PHT) is the primary cardiac impact in TI, driving congestive heart failure (CHF).
    • High cardiac output (CO) from hypoxia and increased pulmonary resistance (PVR) are key contributors to PHT in TI.
    • Doppler tricuspid gradient measurement is crucial for assessing PHT and guiding transfusion therapy in TI.