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In Vitro Analysis of E3 Ubiquitin Ligase Function
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In Vitro Analysis of E3 Ubiquitin Ligase Function

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In vitro assembly and recognition of Lys-63 polyubiquitin chains.

R M Hofmann1, C M Pickart

  • 1Department of Biochemistry and Molecular Biology, School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.

The Journal of Biological Chemistry
|May 23, 2001
PubMed
Summary

Lysine-63 (Lys-63) linked polyubiquitin chains signal substrate degradation but are not required for error-free DNA repair, according to new findings in Saccharomyces cerevisiae.

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