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[Evidence-based surgery in colon carcinoma].
1Chirurgische Klinik, Carl-Thiem-Klinikum Cottbus. IGastinger@aol.com
Zentralblatt Fur Chirurgie
|May 24, 2001
Summary
Evidence-based colon cancer therapy remains limited, with only about 10% of surgical approaches supported by controlled studies. Further research and multi-center studies are crucial for advancing colon cancer treatment.
Area of Science:
- Oncology
- Surgical Oncology
- Evidence-Based Medicine
Background:
- Colon cancer therapy lacks a strong foundation in controlled study results.
- A significant portion of therapeutic approaches are not evidence-based.
Purpose of the Study:
- To analyze the evidence base for colon cancer therapy between 1980-2000.
- To identify therapeutic areas supported by controlled studies.
Main Methods:
- An extensive internet search was conducted to retrieve 965 abstracts on colon cancer therapy.
- Studies were categorized into retrospective, prospective randomized, prospective non-randomized, and review articles.
Main Results:
- Only a small fraction (approximately 10%) of colon surgery is evidence-based.
- Controlled study results support perioperative antibiotic prophylaxis, mechanical intestinal cleansing, anastomosis techniques, and early nutrition.
- Significant numbers of retrospective and review articles were identified, but fewer prospective studies.
Conclusions:
- There is a substantial gap in evidence-based practice for colon cancer therapy.
- The importance of pathology results for surgical resection and consideration of multi-center studies are highlighted.