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Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Spinal cord tolerance to high-dose fractionated 3D conformal proton-photon irradiation as evaluated by equivalent uniform dose and dose volume histogram analysis.

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Related Experiment Video

Updated: May 21, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Uveal melanomas. Conservation treatment.

J E Munzenrider1

  • 1Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Hematology/Oncology Clinics of North America
|May 24, 2001
PubMed
Summary

Eye-sparing treatments like proton beam and plaque radiotherapy offer high local control rates for uveal melanoma. These advanced therapies preserve vision and the eye, demonstrating oncologic success without compromising survival.

Area of Science:

  • Ophthalmology
  • Radiation Oncology
  • Medical Physics

Background:

  • Uveal melanoma treatment traditionally involved eye removal (enucleation).
  • Eye conservation is now achievable through external beam charged particle (proton) therapy and episcleral radionuclide plaque therapy.
  • Tumor size and location significantly influence the success of visual preservation and eye retention.

Purpose of the Study:

  • To evaluate the efficacy of eye-sparing techniques in treating uveal melanoma.
  • To assess the impact of tumor characteristics on treatment outcomes.
  • To compare different radiotherapy modalities for uveal melanoma management.

Main Methods:

  • External beam charged particle (proton) therapy.
  • Episcleral radionuclide plaque therapy (e.g., 125I).

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  • Dose-searching trials and comparative studies (e.g., UCSF-LBL trial).

    • Main Results:

    • High rates of local control (75-80% eye salvage) are achievable with both proton and plaque therapy.
    • Proton beam therapy shows superiority over plaque therapy in local tumor control and eye retention.
    • Useful vision can be preserved, especially in tumors favorably located near the optic disc or macula.
    • Survival rates are not compromised compared to enucleation.

    Conclusions:

    • Conservative radiotherapy techniques are highly effective for uveal melanoma, offering excellent local control and eye retention.
    • Charged particle therapy demonstrates superior outcomes compared to plaque brachytherapy.
    • Further research into adjuvant systemic therapies is needed for metastatic disease.