Related Experiment Videos

Increased plasminogen activator inhibitor activity and diabetes predict subsequent coronary events in patients with

K Takazoe1, H Ogawa, H Yasue

  • 1Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan.

Annals of Medicine
|May 24, 2001
PubMed

Insights

Higher plasminogen activator inhibitor (PAI) activity and diabetes mellitus are key predictors of future coronary events in angina patients. Lower PAI activity offers protection, even in diabetic individuals.

Area of Science:

  • Cardiology
  • Diabetology
  • Clinical Biochemistry

Background:

  • Plasminogen activator inhibitor (PAI) is a recognized marker for myocardial infarction recurrence.
  • Diabetes mellitus is a significant risk factor for coronary artery disease, including myocardial infarction and angina pectoris.

Purpose of the Study:

  • To evaluate baseline plasma PAI activity, clinical variables, and angiographic findings as predictors of future coronary events.
  • To assess risks for sudden death, nonfatal myocardial infarction, and revascularization procedures during follow-up.

Main Methods:

  • A 4-year prospective study involving 249 consecutive patients admitted for angina pectoris.
  • Blood samples for PAI activity measurement were collected at discharge.

Main Results:

  • PAI activity and diabetes mellitus were identified as independent risk factors in multivariate analysis.
  • Higher PAI activity (≥ 8.4 IU/mL) and diabetes presence reduced event-free survival.
  • Patients with both high PAI activity and diabetes had a 4.2-fold increased risk compared to those with low PAI activity and no diabetes.

Conclusions:

  • Elevated PAI activity and diabetes mellitus predict subsequent coronary events in angina patients.
  • Diabetes has diminished prognostic value for coronary events when PAI activity is low.
Abstract

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...