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Sexual dysfunction in hypertensive patients treated with losartan
J L Llisterri1, J V Lozano Vidal, J Aznar Vicente
1Department of Medicine and Psychiatry, University of Valencia School of Medicine, Spain.
The American Journal of the Medical Sciences
|May 24, 2001
Summary
Losartan therapy significantly improved erectile function, sexual satisfaction, and frequency in hypertensive men. This treatment also positively impacted overall quality of life for patients with high blood pressure.
Area of Science:
- Cardiology
- Urology
- Pharmacology
Background:
- Erectile dysfunction (ED) is linked to hypertension and can be a side effect of antihypertensive medications.
- This study investigates the impact of losartan on sexual function in men with uncontrolled hypertension.
Purpose of the Study:
- To evaluate the effect of 12-week losartan therapy on sexual dysfunction in hypertensive men.
- To assess changes in sexual satisfaction, frequency, and quality of life.
Main Methods:
- A prospective interventional study involving 82 men with uncontrolled hypertension and ED.
- Participants received 12 weeks of losartan therapy (50-100 mg/day).
- Sexual function was assessed using a validated self-administered questionnaire before and after treatment.
Main Results:
- Losartan significantly improved sexual satisfaction (7.3% to 58.5%) and frequency of sexual activity.
- High frequency of sexual activity increased from 40.5% to 62.3%; low frequency decreased significantly.
- Quality of life improved in 73.7% of patients; losartan had a non-significant effect on sexual function in men without ED.
Conclusions:
- Losartan therapy demonstrates a positive impact on erectile function, sexual satisfaction, and activity frequency in hypertensive men.
- The drug may offer an added benefit of improving quality of life, a crucial factor in hypertension management.