Related Experiment Video
Updated: Aug 17, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
Synonymous codon bias is not caused by mutation bias in G+C-rich genes in humans
1Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton BN1 9QG, England.
Abstract:
It is has been suggested that synonymous codon bias is a consequence of mutation bias in mammals. We tested this hypothesis in humans using single-nucleotide polymorphism data. We found a pattern of polymorphism which was inconsistent with the mutation bias hypothesis in G+C-rich genes. However, the data were consistent with the action of natural selection or biased gene conversion. Similar patterns of polymorphism were also observed in noncoding DNA, suggesting that natural selection or biased gene conversion may affect large tracts of the human genome.
Related Concept Videos
The Central Dogma
From DNA to Protein
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Genome Copying Errors
The Central Dogma
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
Gene Evolution - Fast or Slow?
In contrast, regions which code...

