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Related Experiment Videos

Sex differences in HAART-associated dyslipidaemia.

H Pernerstorfer-Schoen1, B Jilma, A Perschler

  • 1Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, University of Vienna Medical School, Vienna General Hospital, Vienna, Austria.

AIDS (London, England)
|May 24, 2001
PubMed
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Highly active antiretroviral therapy (HAART) causes more metabolic side effects in women than men, potentially reducing their natural protection against atherosclerosis. This study investigated sex differences in HAART

Area of Science:

  • Cardiovascular Health
  • Infectious Diseases
  • Metabolic Disorders

Background:

  • Female sex typically confers protection against dyslipidemia and atherosclerosis.
  • Highly active antiretroviral therapy (HAART) is a critical treatment for HIV/AIDS.
  • Understanding sex-specific metabolic effects of HAART is crucial for patient management.

Purpose of the Study:

  • To investigate potential sex differences in metabolic side effects of HAART.
  • To correlate metabolic changes with endothelial cell activation (measured by cE-selectin).
  • To assess if HAART alters the protective cardiovascular profile observed in women.

Main Methods:

  • Prospective longitudinal cohort study at a tertiary care center.
  • Enrolled HIV-seropositive men (n=27) and women (n=13) with high viral load, and 35 healthy controls.

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  • Measured serum lipids, insulin, leptin, and circulating E-selectin (cE-selectin) at baseline, 3, and 6 months post-HAART initiation.

    • Main Results:

    • HAART increased triglycerides, leptin, and LDL cholesterol, with more pronounced effects in women.
    • Fasting insulin and LDL:HDL ratio increased only in female HIV patients.
    • Endothelial activation (cE-selectin) decreased more in men; women showed higher triglycerides and leptin post-therapy.

    Conclusions:

    • Metabolic adverse effects of HAART are more pronounced in women than in men.
    • Female HIV-infected patients may lose some of their natural protection against atherosclerosis during HAART.
    • Sex-specific monitoring and management strategies for HAART-related metabolic complications are warranted.